尼膜同和依那普利对糖尿病脑卒中患者胰岛素敏感性的影响

The effects of Nimotop and Enalapril on insulin sensitivity in patients suffering from stroke with diabetes

目的 研究尼膜同和依那普利对糖尿病脑卒中患者胰岛素敏感性的影响 ,探讨该病患者的高血压治疗。方法 用放射免疫法检测患糖尿病、高血压、单纯高血压脑卒中患者、对照组血清胰岛素水平及尼膜同和依那普利治疗后糖尿病脑卒中患者胰岛素敏感性的变化。结果 患糖尿病高血压、单纯高血压脑卒中患者血清胰岛素水平较对照组显著增高 ( P <0 .0 0 1 ;P <0 .0 0 5) ;在改善胰岛素敏感性方面 ,依那普利的作用优于尼膜同 ( P <0 .0 5)。结论 高胰岛素血症在高血压发病中具有重要意义 ;依那普利在降低血压的同时对胰岛素敏感性具有肯定的改善作用 ;对患有糖尿病的脑卒中患者 ,控制血压应首选依那普利。

Objective To study the effects of nimotop and enalapril on insulin sensitivity in patients suffering from stroke with diabetes and explore the treatment for hypertension of the patients.Method The level of serum insulin in patients suffering from stroke with diabetes and hypertension,the patients suffering from stroke with hypertension only and control and the changes of insulin sensitivity of patients suffering from stroke with diabetes and hypertension after treated by nimotop and enalapril were examined by radioimmunoassay.Results The level of serum insulin in patients suffering from stroke with diabetes and hypertension or with hypertension only was higher than that in control(P<0.001;P<0.005);as for improving the insulin sensitivity,enalapril was superior to nimotop(P<0.05).Conclusion High serum insulin has important significance for mechanism of hypertension; enalapril has positive effects on improving the insulin sensitivity except lowering blood pressure; enalapril is the first selection for treating hypertension of patients suffering from stroke with diabetes.