前列腺特异抗原对诊断前列腺癌的价值

The value of prostate specific antigen in the diagnosis of prostate tumor

目的 :联合检测血清中总 PSA(t- PSA)、游离 PSA(f- PSA)以及 f- PSA/ t- PSA比值 ,探讨其对前列腺癌 (PCa)的诊断价值。方法 :采用微粒子酶免疫法 (MEIA)检测 6 2例正常人、78例前列腺增生症 (BPH)和 2 4例PCa患者血清中 t- PSA、f- PSA,并得出 f- PAS/ t- PSA比值。计算资料以 x± s表示 ,两组均数比较经 t检验。结果 :单独以 t- PSA >4.2μg/ L或 f- PSA >0 .93μg/ L作为对 PCa的诊断指标 ,其特异性分别为 6 1.5 %、42 .3% ,阳性检出率分别为 6 4.5 %、42 .9% ,而以 f- PSA/ t- PSA比值 <0 .11作为对 PCa的诊断指标 ,其特异性和阳性检出率分别为 87.2 % ,83.4% ,显著高于 t- PSA和 f- PSA(P <0 .0 0 1)。结论 :当血清 t- PSA超过正常时 ,f- PSA/ t- PSA的比值对 PCa和

Purpose:To evaluate the PSA value in diagnosing prostatic tumors by integrally testing the serum t PSA, free PSA (f PSA) as well as ratio of f PSA/t PSA.Methods:The serum t PSA, f PSA of 62 normal people, 78 with benign prostate hyperplasia and 24 with prostate cancer were measured by particle enzyme immunoassay (MEIA), to find out the ratio of f PSA/t PSA.Results:When using t PSA> 4.2 μg/L or f PSA> 0.93 μg/L alone as prostate cancer diagnostic criterion, its specificity were 61.5 %, 42.3 % and the positive detectable rate were 64.5 % and 42.9 % respectively.But when using the ratio of f PSA/t PSA< 0.11 as the diagnostic criterion, its specificity and positive detectable rate were 87.2 % and 83.4 % respectively, much higher than that of t PSA, f PSA (P< 0.01 ).Conclusion:When serum t PSA higher than normal, the ratio of f PSA/t PSA is of great clinical value in differentiating the prostate cancer from the benign prostate hyperplasia (BPH).