增效依托红霉素胶囊的药效学与含量测定

Evaluation of content of estolate in capsule containg TMP and estolate and thera peutic efficacy

目的：研究增效依托红霉素胶囊的药效与含量测定。方法：采用微生物效价法，在样品不经分离的情况下，测定增效依托红霉素胶囊中依托红霉素的含 量。 培养基：Ⅱ号pH7.8 ；缓冲液：磷酸盐缓冲液，pH7.8；检定菌：枯草芽孢杆菌［CMCC(B)63501］;抗生素浓 度范围1～5 u·ml-1。 结果：建立了增效依托红霉素胶囊中依托红霉素含量的测定方法。依托红霉素和TMP联用对大肠杆 菌有相加作用。 结论：依托红霉素和TMP联用可提高药效，具有一定的临床应用价值。

：OBJECTIVE To evaluate contents of estolate in capsules containing trimethroprim(TMP) and estolate and the pharmacokinetics. METHODS A biological method was used for evaluating content of es tolate in the capsules.The concentration range was 1～5 u·ml-1. RESULTS A procedure has been developed for evaluation of contents of estolate in the compound capsules. The combination showed the synergy to colibacillus. CONCLUSIONS The advantage of the TMP and estolate was the synergistic angmentation of the th erapeutic efficacy.