肝硬化中国小型猪结扎肝右静脉后对门静脉压力的影响

Influence of right hepatic vein ligation on porta vein pressure in cirrhotic Chinese small pig

目的 探讨结扎肝硬化中国小型猪肝右静脉后对其门静脉压力 (PVP)的影响。方法 12只中国小型猪建立肝硬化模型后 ,戊巴比妥钠腹腔麻醉下剖腹 ,B超介导下结扎肝右静脉 ,选取一支大网膜静脉置管测量结扎前及结扎后 30min及 1,3 ,5 ,7,14 ,2 1,2 8,5 6d的PVP。结果 剖腹手术均顺利完成 ,手术后均发生PVP升高 ,6只小猪术后PVP超过 35cmH2 O ,且其中 4只小猪出现上消化道出血 ,呈自限性。术中术后无一例死亡。结论 肝硬化条件下结扎肝右静脉会引起PVP早期升高 ,后期呈下降趋势 ;压力过高者会造成早期上消化道出血。

Objective To investigate the influence of right hepatic vein ligation on pressure(PVP) in cirrhotic Chinese small pig.Methods Under the guidance of B-ultrasound, right hepatic veins in 12 cirrhotic pigs were ligated.A tube was placed into one vein of omentum and PVP was measured before and 30 min, 1, 3, 5, 7, 14, 21, 28 and 56 days after operation. Results\ PVP of all pigs raised. PVP exceeded over 35 cmH 2O in 6 pigs and 4 upper digestive tract. Hemorrhage occured in 4 pigs. Conclusion\ PVP is elevated of right hepatic vein is ligated in cirrhotic pig. Hemorrhage of upper digestive tract is possible if PVP is too high.