优赛清栓剂的研制与临床应用

Preparation and Clinical Application of Yousaiqing Suppository

目的 :研制治疗溃疡性结肠炎的栓剂和考察其临床疗效。方法 :采用RP -HPLC法测定优赛清栓中对氨基水杨酸和盐酸黄连素的含量 ,并同柳氮磺胺吡啶栓进行对照 ,观察其临床疗效。结果 :控制制剂的质量方法可行 ,治疗溃疡性结肠炎的有效率达70 7 %。结论 :优赛清栓的质量控制方法简便、可靠 ,适用于常规分析 ;临床疗效好。

OBJECTIVE:To prepare Yousaiqing suppository for treating ulcerative colitis and observe its clinical therapeutic effect METHODS:The ingredients of suppository,PASA and berberine HCl,were determined with RP-HPLC and the therapeutic effect was observed in comparison with sulfasalazine suppository RESULTS:This method of quality control was feasible and the effective rate for ulcerative colitis amounted to 70 7% CONCLUSION:The quality control method is simple,reliable and suitable to routine analysis and the therapeutic effect is satisfactory