双黄连与3种不同药物配伍前、后微粒的变化

The Changes of Insoluble Particles of Shuanghuanglian in Quantity After Mixed With Three Different Drugs

目的 :考察双黄连与青霉素、头孢拉定、地塞米松3种不同注射剂配伍前、后的不溶性微粒变化。方法 :利用ZWF -4D型注射液微粒分析仪分别计数双黄连与3种注射剂配伍前后≥2 0、≥5 0、≥10 0和≥25 0μm的微粒数 ,并进行比较。结果 :双黄连与青霉素配伍后的不溶性微粒数明显多于配伍前 ,≥5 0μm、≥10 0μm、≥25μm分别增加2、23、94倍 ,而头孢拉定、地塞米松与双黄连配伍后的不溶性微粒也明显多于配伍前 ,但低于青霉素与双黄连配伍后的不溶性微粒数。结论 :临床在用双黄连与这些药物联合应用时 ,宜分别放入2个输液瓶内应用 ,以避免不溶性微粒数的增加及不良反应发生率的上升。

OBJECTIVE:To observe the changes of insoluble particles of shuanghuanglian in quantity after mixed with benzylpenicillin,cefradine and dexamethasone in normal saline.METHODS:Using ZWF-4D particle counter,the number of insoluble particles in sizes of ≥2.0μm,≥5.0μm,≥10.0μm and ≥25.0μm was counted and compared before and after mixed with above-mentioned three drugs.RESULTS:The insoluble particles of Shuanghuanglian were obviously increased after mixed with benzylpenicillin,the particles in sizes of ≥5.0μm,≥10.0μm and ≥25.0μm increased twice,23 and 94 times respectively.The insoluble particles were also increased after mixed with cefradine or dexamethasone,however,the increase rate was lower in comparison with that mixed with benzylpenicillin.CONCLUSION:Shuanghuanglian,used in combination with above-mentioned drugs,should be put into separate infusion bottle to avoid the increase of insoluble particles and ADRs.