两价钯催化下烯醇钯中间体和亲电试剂的反应研究

Reactions of Palladium Enolate Intermediate with Electrophiles under Divalent Palladium Catalysis

根据在两价钯催化的亲核试剂-炔烃-α,β-不饱和羰基化合物的串联加成反应中所假设的烯醇钯中间体的机理,研究了炔酸烯丙酯化合物1和亲电试剂在两价钯催化下的反应.使用乙酰氯作为亲电试剂得到了β-乙酰氧基烯基-γ-丁内酯3,这一结果为烯醇钯中间体的机理提供了一个实验证据.

According to the mechanism involving palladium enolate intermediates in divalent palladium catalyzed nucleophile-alkyne-alpha,beta -unsaturated carbonyl tandem additions, the reactions of the enyne ester 1 with electrophiles under the catalysis of divalent palladium were examined. Employing acetyl chloride as the electrophile afforded the beta -acetoxyvinyl-gamma -butyrolactone 3 as the product, which provided an experimental evidence to the mechanism involving the palladium enolate intermediate.