茼蒿素类似物的分子多样性2—（Z）—亚苄基—1，6，9—三氧杂螺环[4,5]癸—3—烯类化合物的合成

Molecular Diversity of Tonghaosu Analogs Synthesis of 2 - ( Z ) - Benzylidene - 1,6,9 - trioxaspiro[ 4,5] dec - 3 -ene

有多种生物活性的茼蒿素类似物是一类具有螺环缩酮烯醚独特结构的化合物,本文报道用糠醇为原料,以我们的呋喃二醇脱水-螺环缩酮化反应为关键反应,合成了一类三氧杂螺环-[4,5]-癸烯类的新型茼蒿素类似物.为这类化合物的分子多样性开辟了新的途径.

By using the dehydration - spiroketalization of corresponding furanyldiols discovered in our laboratory as the key reaction to construct the trioxaspiro [4, 5] dec - 3 - ene nucleus, we have developed a practical synthetic route to Tonghaosu analogs, a class of compounds characterized by a unique spiroketal enol ether motif, and thus created an expeditious access to the molecular diversity of this type of substances that already show interesting activities in preliminary biological tests.