烯酮缩胺与芳基异硫氰酸酯的反应——合成异噻唑化合物的一个途径

Reaction of Ketene Aminals with Aryl Isothiocyanates——A Simple Route to Isothiazole Compounds

具有不同取代基的环状和非环状的烯酮缩胺与芳基异硫氰酸酯在丙酮中回流,可高产率地获得α-碳加成产物,该产物在溴存在下可氧化关环生成异噻唑类化合物.

Cyclic and acyclic ketene aminals with different electron withdrawing groups reacted with aryl isothiocyanates to give the corresponding alpha - carbon adducts in high yield which underwent oxidative cyclization with bromine to afford isothiazole compounds in moderate yield.