慢性乙肝患者NK、ADCC活性及其对IFN-α、IFN-γ的反应

NK、 ADCC Activities Patients with Chronic Hepatitis and Their Responses to IFN-α and IFN-γ

本文用Hela细胞乳酸脱氢酶释放法测定了42例慢性乙肝病人外周血NK、ADCC活性及其对IFN-α100U/ml、500U/ml及IFN-γ500U/ml预处理4小时后的反应。结果显示,病人PBL NK,ADCC活性与正常对照有显著差别,经IFNs处理后,其NK或/和ADCC活性均有不同程度的升高反应,从而提示了IFNs在慢性肝病治疗中的重要作用。

NK, ADCC acivities in the peripheral blood of patients with chronic hepatitis were measured using Hela cells as target cells. NK activity was significantly lower in patients with CAH compared with healthy controls and significantly higher in patients with CPH. After PEL of all patients having been precultured with IFN-α(100U/mI, 500U/ml) . IFN-λ (500U/ml) for 4 hrs, the NK or/and ADCC activities were elevated to normal levels. The results indicate that IFNs may be useful for treatment of patients with chronic hepatitis.