摘要
本文采用^(51)Cr释放试验测定人重组白细胞介素6(HrIL-6)处理正常成人睥单个核细胞(MNC)24小时后,NK细胞抗K562靶细胞的杀伤活性。结果证实,IL-6能明显增强脾NK细胞的抗瘤活性(P<0.05,与对照组比较),且可诱导MNC产生IL-2,NK活性的增强效应和MNCIL-2的合成水平均与IL-6的处理剂量呈依赖关系,提示IL-6促人脾NK活性的机制可能是通过诱导脾细胞产生IL-2而实现的。
The modulation of human recombinant IL-6 (HrlL- 6 ) on NK cell activity of human spleens against K562 tarSet Cells in a 4-hr 51Cr release assay was reported. We demonstrated that IL- 6 significantly enhanced NK activity compared with control cultured without HrlL- 6 for 24 hr (P<0.05) and induced mononuclear cells derived from spleens to produce IL-2. Both of IL-6-induced NK activity and IL-2 activity were dose dependent, suggesting that IL-6 enhances the lytic activity of NK cells via IL-2.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1991年第3期155-157,154,共4页
Immunological Journal
基金
国家自然科学基金38900053号
山东省自然科学基金资助课题
