EB病毒与非霍奇金淋巴瘤——附180例报道

Association between Epstein-Barr Virus and no-Hodgkin's Lymphomas

目的 探讨 NHL与 EBV感染的相关性。方法 用 ISH方法检测 1 80例 NHL中EBV编码的 RNA( EBER1 /2 )。结果 ( 1 ) EBER1 /2感染率为 42 .8% ( 77/1 80 ) ,感染率依次为TCL64.8%、NK/T46.2 %、BCL9.5 %。其中 TCL、NK/T与 BCL相比 ,P≤ 0 .0 0 5 ;( 2 )结内、结外EBV感染率依次为 2 2 .2 %、5 3.8% ,有显著差异 ,P<0 .0 0 5 ;( 3)面中线 (鼻腔 /口咽环 ) EBER1 /2感染率 72 .4% ( 5 5 /76) ,多形细胞性 EBER1 /2感染率 70 .1 % ( 5 4 /77)。结论 本地区 NHL与 EBV感染关系密切 ,TCL、NK/T淋巴瘤感染率明显高于 BCL。

Objective To explore the relationship between NHL and EBV.Methods In 180 cases of NHL,the presence of EBV encoded small RNA(EBER1/2) was detected by ISH.Results(1)EBER1/2 positivity was found in 77 of 180(42.8%) NHLs, including 64.8% of TCLs,46.2% of NK/T cell lymphomas and 9.5% of BCLs.The positive rates of EBER1/2 in TCLs and NK/T cell lymphomas were significantly higher than that in BCLs ( P <0.005);(2) There was a significant difference in the positive rates of EBER1/2 in intra (22.2%) and extra nodal(53.8%) NHLs ( P <0.005);(3)The frequencies of EBV infection in midline facial tumors (of nasal cavity/oropharynx ring) and pleomorphic TCL were 72.4% (55 of 76) and 70.1%(54 of 77) respectively. Conclusion NHL has strong relations with EBV,the frequencies of which in TCLs and NK/T cell lymphomas were significantly higher than that in BCL and associated with the localizations and subtypes.