大肠癌临床病理因素与预后关系的Cox模型分析

Analysis of Cox Model for Clinical Pathology Factors with Prognosis in Colorecatal Cancer

目的 探讨临床病理因素对大肠癌预后的影响。方法 收集 81 7例大肠癌患者诊治信息 ,应用 Kaplan- meier法和 Cox模型 ,对有关临床病理因素进行生存及预后因素分析。结果 失访率 5 .1 4% ,全组 3、5、1 0年生存率分别为 5 9.92 % ,48.2 7%和 34.0 2 %。多因素 Cox模型分析显示影响大肠癌预后的临床病理因素为淋巴结转移 ,Dukes'分期及组织学类型。

Objective To explore the influence of pathology factors on prognosis of colorectal cancer,817 cases with colorectal cancer were selected to study.Methods Using Kaplan Meier's method and Cox model,analysis of survival and prognostic factors were performed to some clinical pathology factors that influenced the prognosis of colorected cancer.Results Result showed that rate of loss to follow\|up was 5.14% and the over\|all survival rate were 59.92% at 3 years,48.27% at 5 years and 34.02% at 10 years separately.The result of multivariate Cox model analysis showed that the significant prognostic factors of pathology factors were lymph node metastasis,Duke's stage and histological type.Conclusion Clinical pathology factors were important indexes for identifing the prognosis of colorectal cancer.