三种叶片式血泵的体外溶血试验研究

In Vitro Hemolysis Test About the Three Kinds of the Impeller Blood Pumps

血泵对血液的破坏程度是衡量血泵性能的一个重要指标。本文针对三种叶片式血泵即离心泵、轴流泵、混流泵的溶血试验做一比较分析。在试验中 ,选用了我们研制的Ⅰ型离心血泵、磁耦合型轴流血泵、螺旋混流泵。在一封闭管道中 ,注入新鲜抗凝羊血 5 0 0ml,水浴温度 37℃ ,血泵辅助流量为 5L min ,平均压力10 0mmHg,分别在泵转后 0、 0 5、 1 0、 1 5、… 4 0h测量血浆中游离血红蛋白 (FHB)和纤维蛋白原 (FIB)含量 ,最后计算出三个血泵整个过程中的标准溶血指数NIH。结果表明三种血泵对血液都有一定的破坏 ,它们的NIH值分别为 0 112 5± 0 0 15 7g 10 0L、 0 0 931± 0 0 137g 10 0L和 0 0 5 6 1± 0 0 0 5 8g 10 0L ,由此可得出混流泵对血液的破坏最小。

For a blood pump, the damage to blood is a very important for evaluating it. In this paper, we discussed hemolysis test about three kinds of impeller blood pumps. In vitro experiment, a mode I centrifugal pump, a magnetic coupling axial flow pump and a spiral mixed pump were selected. 500ml anticoagulant sheep blood were input into a closed pipeline loop. The simulated conditions were: 5L/min flowrate, 100mmHg average pressure and 37°C temperature of water bath. When the pump had rotated for 0, 0.5, 1.0, 1.5, · · · 4.0 hours, we measured the free plasma hemoglobin and fibrinogen. At last, normalized indexes of hemolysis for the three pumps were calculated. The results showed that the values of NIH were 0.1125 ± 0.0157g/100L, 0.0931 ± 0.0137g/100L 0.0561 ± 0.0058g/100L, respectively. All the three blood pumps caused different levels of damage to the blood. The best hemolysis results were from the mixed blood pump.