心安颗粒毒理学实验研究

TOXICOLOGICAL STUDY OF XIN 'AN KE LI

目的 :研究心安颗粒的毒性作用。方法 :采用最大耐受量测定法及长期连续给药法分别观察其急性毒性和长期毒性。结果 :最大耐受量为 172 .8g(生药 ) /kg/日 (相当于临床成人 1日量的 345 .6倍 )。长期毒性试验结果显示 ,大鼠的一般情况、体重、血象、肝肾功能及病理检查等与对照组比较无明显差异 (P >0 .0 5 )。结论

Objective: To study the toxicity of Xin An Ke Li. Methods: The maximum endurance dose was determined. In order to observe the long-term toxicity the drug was continuously given per os. Results:Maximum endurance dose was 172.8g/kg/d, and there was no obvious long-term toxicity in general conditions,peripheral blood picture, function of liver and kidney, and pathological histology in rats. Conclusion: Xin An Ke Li has no obvious toxicity.