苯那普利联合小剂量双氢克尿噻治疗高血压疗效观察

EFFECTIVENESS OF BENAZEPRIL IN COMBINATION WITH LOW-DOSE HYDROCHLOROTHIAZIDE FOR ESSENTIAL HYPERTENSION

目的 :探讨苯那普利与小剂量双氢克尿噻联合治疗高血压疗效及其对代谢的影响。方法 :48例高血压病患者随机分为两组 ,苯那普利组 :苯那普利 5～ 10mg ,每日 1次或两次口服 ;苯那普利联用双氢克尿噻组 :苯那普利 10mg加服双氢克尿噻 12 .5mg,每日 1次。两组均治疗 8周 ,治疗前后测基础血压、空腹血糖、血脂、血尿酸、血钾、血肌酐以及治疗前后 2 4小时动态血压检测。结果 :①苯那普利联合小剂量双氢克尿噻组较单用苯那普利组降压总有效率明显提高 ,2 4小时动态血压负荷下降显著改善。②两组治疗前后对代谢无明显改变。结论 :苯那普利联合小剂量双氢克尿噻治疗高血压优于单用苯那普利组 。

Objective:To survey the effect of benazepril in combination with low-dose hydrochlorothiazide on the blood pressure in hypertersive patients. Methods: Forty essential hypertensive patients were randomly divided into two groups to take one of the following regimen for 8 weeks: ①benazepril (50～100mg qd or Bid);②benazepril (10mg qd) + hydrochlorothiazide (12.5mg qd). Blood pressure, metabolic parameters such as fast blood glucose, blood lipid, blood potassium, blood creatinine and uric acid were evaluated before and after drug therapy. Results: Total response rate was higher in benazepril in combination with low-dose hydrochlorethiazide group than that of benezepril group. Metabolic parameters had no significant change in the two groups after treatment. Conclusion: Benazepril in combination with low-dose hydrochlorothiazide are more effective than benazepril alone in the treatment of hypertension and there is no significant adverse effect on metabolism.