1H-1,2,3-三唑的合成

SYNTHESIS OF 1H-1,2,3-TRIAZOLE

目的 :研究适宜大量制备 1H 1,2 ,3 三唑的合成方法。方法 :以邻苯二胺为原料 ,经重氮化、环合、氧化、脱羧 ,制得 1H 1,2 ,3 三唑。结果 :所得产物的结构经1HNMR ,13CNMR ,MS EI确证 ,并且产物熔点与文献报道一致 ,总收率 4 2 .0 %。结论 :该方法操作简便 ,反应条件温和 ,适宜工业规模制备 1H 1,2 ,3

OBJECTIVE:A new synthesis procedure of 1H 1,2,3 Triazole suitable for reasonably large scale preparation has been developed. METHODS:1,2 phenylenediamine is converted to benzotriazole via NaNO 2/CH 3COOH which then is oxidated with KMnO 4 to 1,2,3 triazole 4,5 dicarboxylic acid and decarboxylation to 1,2,3 triazole in the presence of Cu powder.RESULTS:The product was confirmed by 1HNMR, 13 CNMR,MS and the total yield was about 42.0% . CONCLUSION:The advantages of this method are safe and convenient for work up.