心先安对犬缺血心肌功能的影响

EFFECT OF MEGLUMINE CYCLIC ADENYLATE ON ISCHEMIC MYOCARDIAL FUNCTION IN DOG

目的 :观察心先安对犬缺血心肌收缩和舒张功能的影响。方法 :实验犬缝扎左冠状动脉前降支远端 1/ 3 ,于缺血即刻及缺血后 10～ 3 0min应用左心导管技术测量缺血状态心功能的变化 ;之后缓慢静脉注射心先安 3mg·kg 1,注毕 10～ 60min ,每隔 10min重复一次心导管测量。结果 :应用心先安后左室收缩压升高 ,左室舒张末压下降 ,左室松驰时间常数明显缩短 ,同时心率减慢 ;其作用高峰在注射后 2 0～ 3 0min左右。结论 :心先安可改善犬缺血心肌的收缩与舒张功能 。

OBJECTIVE:To observe the effect of meglumine cyclic adenylate on ischemic myocardial both systolic and diastolic function. METHODS:The left anterior descending of the coronary arteries were ligated completely in 10 dogs,left ventricule pressure by catheter technique and ECG were measured,then meglumine cyclic adenylate, 3 mg·kg 1 ,injected,after that recorded left ventricule pressure every 10 minutes RESULTS:Left ventricular systolic pressure increased,left ventricular and diastolic pressure decreased Left ventricular relaxation time constant(T)shortened,heart rate decreased,but just maintained a relative short time. CONCLUSION:The meglumine cyclic adenylate improves systolic and diastolic function of ischemic left ventricles.