胃癌术后大剂量5-氟脲嘧啶、丝裂霉素腹腔化疗

Cancer of stomach celiac chemotherapy of a mass of 5 - FU and MMC after surgery

目的预防腹腔内恶性肿瘤种植性转移,提高胃癌根治术后生存率。方法术中行腹腔内5-氟脲嘧啶及丝裂霉素灌洗,术后早期大剂量5-氟脲嘧啶、丝裂霉素腹腔联合化疗,持续静脉化疗。结果全组实行一疗程腹腔化疗后,无严重毒副作用,无肝、肾及血液功能损害,无严重的腹腔并发症。随访4～18个月,无1例腹腔及切口种植性转移。结论大剂量腹腔内化疗,安全、简便、易行,适合于基层医院,对预防腹腔种植性转移疗效满意,前景可观。

Objective To prevent generalized abdominal carcinomatosis and to raise the survival rate of stomach cancer patients who had radical operation. Methods Laving abdomen by 5 - FU and MMC during operation and using celiac combined chemotherapy of a large amount of 5 - FU and MMC early in the postoperative period , following with venous chemotherapy. Results After one period of chemotherapy on all patients, no serious side or tocxic effect, no harm to liver, kidney and blood system, no serious celiac syndrome. Follow - up survey for 4 ～ 18 months, no one case has celiac metastasis and wound metastasis.Conclusions Celiac chemotherapy of great dosage is safe, simple, easy and suited to basal hospital, Curative effect is satisfied on preventing abdominal carcinomatosis.The prospect is optimistic.