摘要
朗格汉斯细胞是皮肤中重要的抗原提呈细胞 ,能通过表达某些趋化因子如巨噬细胞炎性蛋白、巨噬细胞来源的趋化因子、巨噬细胞炎性蛋白 - 1α、单核细胞趋化蛋白、FK及一些趋化因子受体如CCR1、CCR5、CCR7等来促使其趋化至皮肤组织 ,摄取抗原后再通过淋巴管迁移至淋巴结T细胞区完成抗原提呈功能。近年来也发现了多种新的趋化因子并对其结构、功能有了初步认识。对朗格汉斯细胞与趋化因子关系的了解有利于加深对某些皮肤病如皮肤利什曼病、HIV的感染等发病机制的认识并提出新的治疗策略。
出处
《国外医学（皮肤性病学分册）》
2001年第5期271-273,共3页
Foreign Medical Sciences(Section of Dermatology and Venereology)
参考文献18
-
1Mahalingam S, Karupiah G. Chemokines and chemokine receptors in inffectious diseases. Immunol Cell Biol, 1999,77(6) :469-475.
-
2Wells TN, Proudfoot AE, Power CA. Strategies to interfere with the chemokine network in disease. Chem Immunol, 1999,72: 181-201.
-
3Napolitano M, Santoni A. Structure and function of the CC chemokine receptor (CCR) 8. Forum (Geneva), 1999,9(4):315-324.
-
4Yatagihara S, Komura E, Nagafune J, et al. EB11/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J Immunol, 1998,161 (6): 3096-3102.
-
5Grewal IS, Rutledge B J, Fiorillo JA, et al. Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP- 1. J Immunol, 1997,159 ( 1 ): 401-408.
-
6Hromas R, Gray PW, Chantry D, et al. Cloning and characterization of exodus, a novel beta-chemokine. Blood, 1997,89(9): 3315-3322.
-
7Mohamadzadeh M, Poltorak AN, Bergstressor PR, et al. Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family. J Immunol, 1996,156(9) :3102-3106.
-
8Bazan JF, Bacon KB, Hardiman G, et al. A new class of membrane-bound chemokine with a CX3C motif. Nature, 1997,385(6617):640-644.
-
9Papadopoulos EJ, Sassetti C, Saeki H, et al. Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol, 1999,29(8) :2551-2559.
-
10Tang HL, Cyster JG. Chemokine up-regulation and activated T cell attraction by maturing dendritic cells. Science, 1999,284(5415 ): 819-822.
同被引文献8
-
1张保琴,程万民,胡艳.趋化因子与树突状细胞[J].解剖科学进展,2006,12(1):92-95. 被引量：2
-
2何英利,赵英仁,张树林,杨瑗,刘敏,金燕,刘锦锋.家族聚集性慢性乙型病毒性肝炎患者PBMC免疫相关的基因表达谱[J].细胞与分子免疫学杂志,2006,22(5):620-622. 被引量：2
-
3Morelli AE,Ronchetti RD,Secchi AD,et al.Assessment by planimetry of Langerhans' cell density in penile epithelium with human papillomavirus infection:changes observed after topical treatment[J].J Urol,1992,147(5):1268-1273.
-
4Banchereau J,Steinman RM.Dendritic cells and the control of immunity[J].Nature,1998,392(6673):245-252.
-
5Morelli AE,Sananes C,Di Paola G,et al.Relationship between types of human papillomavirus and Langerhans' cells in cervical condyloma and intraepithelial neoplasia[J].Am J Clin Pathol,1993,99:200-206.
-
6Jarmin DI,Rits M,Bota D,et al.Cutting edge:identification of the orphan receptor G-protein-coupled receptor2 as CCR10,a specific receptor for the chemokine ESkine[J].J Immunol,2000,164(7):3460-3464.
-
7Charbonnier AS,Kohrgruber N,Kriehuber E,et al.Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells[J].J Exp Med,1999,190(12):1755-1768.
-
8Hart DN.Dendritic cells:unique leukocyte populations which control the primary immune response[J].Blood,1997,90(9):3245-3287.
二级引证文献3
-
1吴志龙,刘小明,Ahmad T. Khalaf.尖锐湿疣患者免疫功能的研究进展[J].华中医学杂志,2008,32(2):153-155. 被引量：2
-
2冯进云,饶国洲,刘玉萍,李萍,崔荣,李建红,刘建中,彭振辉.尖锐湿疣表皮CD1a和CD207的表达[J].细胞与分子免疫学杂志,2009,25(5):420-422. 被引量：1
-
3郑燕萍,王群.低危型人乳头瘤病毒感染所致尖锐湿疣皮损中CXCL12和E-cadherin的表达及意义[J].实用医学杂志,2014,30(13):2074-2077. 被引量：3
-
1周双白,李青峰.骨髓间充质干细胞向损伤组织迁移机制的研究进展[J].中华实验外科杂志,2012,29(6):1205-1206. 被引量：3
-
2王赛,周国华.树突状细胞发育与迁移机制的研究进展[J].临床消化病杂志,2015,27(6):389-391. 被引量：3
-
3郭亮,黄河清,徐海伟.内源性NSCs在神经损伤中的激活及迁移机制[J].解剖科学进展,2008,14(4):441-444.
-
4徐世红,谢兴文.骨髓间充质干细胞的相关迁移机制[J].中国组织工程研究与临床康复,2011,15(19):3573-3576. 被引量：7
-
5苏晓慧,孔祥英,林娜.缺血性脑损伤后内源性神经干细胞迁移机制及中医药的调节作用[J].中国组织工程研究,2012,16(27):5103-5107. 被引量：9
-
6余陈佳,于益芝.树突状细胞体内迁移机制研究进展[J].国外医学（免疫学分册）,2002,25(1):53-56. 被引量：1
-
7Yanik M.,Gurel M.S.,Simsek Z.,Kati M.,田中伟.皮肤利什曼病对患者的心理影响[J].世界核心医学期刊文摘（皮肤病学分册）,2005,0(2):30-30.
-
8冀建超,柳琪林,胡森.树突状细胞体内迁移机制研究进展[J].感染．炎症．修复,2003,4(4):246-248.
-
9邢菁,付于.刺络拔罐治疗带状疱疹研究进展[J].辽宁中医药大学学报,2012,14(8):58-60. 被引量：2
-
10赖志豪,谢玉龙,马超,曹虹.细胞黏附分子在单核细胞迁移中的作用[J].细胞与分子免疫学杂志,2015,31(11):1571-1575. 被引量：4
