期刊文献+

恶性黑素瘤核酸疫苗免疫影响因素及对策

下载PDF
导出
摘要 核酸疫苗是近年发展起来的一项新的免疫治疗技术 ,它是将抗原基因克隆到特定的载体 ,使其进入体内后表达并诱导机体产生相应的细胞和体液免疫反应。构建核酸疫苗的关键是选择合适的目的基因并使用高效的载体。核酸疫苗免疫治疗的效果受多种因素的影响 ,很多研究通过探讨不同的优化策略显著提高了其免疫作用 ,在恶性黑素瘤的实验治疗中已经取得了良好的效果 。
作者 李春英
出处 《国外医学(皮肤性病学分册)》 2001年第5期288-290,共3页 Foreign Medical Sciences(Section of Dermatology and Venereology)
  • 相关文献

参考文献17

  • 1Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science, 1990,247(4949 Pt 1 ) . 1465-1468.
  • 2Reimann J, Kaufmann SH. Altemative antigen processing pathways in anti-infective immunity. Curr Opin Immunol, 1997,9(4):462-469.
  • 3Stenger S, Modlin RL. Cytoxic T cell responses to intracellular pathogens.Curr Opin Immunol, 1998,10(4) :471-477.
  • 4Reis e Sousa C, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol,1999, 11 (4):392-399.
  • 5Doe B, Selby M, Barnett S, et al. Introduction of cytotoxic T lymphucytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow derived cells. Proc Natl Acad Sci USA, 1996, 93 (16): 8578-8583.
  • 6Park JH, Kim CJ, Lee JH, et gl. Effective immunotherapy of cancer by DNA vaccination. Mol Cells, 1999,9(4): 384-391.
  • 7Ribas A, Butterfield LH, McBride WH, et al. Genetic immunization for the melanoma antigen MART-1/Melan-A using recombinant adenovirustransduced murine dendritic cells. Cancer Res, 1997,57(14) :2865-2869.
  • 8Zhou WZ, Kaneda Y, Huang S, et al. Protective immunization against melanoma by gp100 DNA-HVJ-liposome vaccine. Gene Ther, 1999, 6(10): 1768-1773.
  • 9Bronte V, Apolloni E, Ronca R, et al. Genetic vaccination with "self" tyrosinase-related protein 2 causes melanoma eradication but not vitiligo.Cancer Res, 2000,60(2) :253-258.
  • 10Krieg AM, Yi Ak, Matson S, et al. CpG, motifs in bacterial DNA trigger direct B-cell activation. Nature, 1995,374 (6522): 546-549.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部