胃动素和胆囊收缩素与肠易激综合征的关系

The Clinical Significance of Plasma MOT and CCK Levels in Irritable Bowel Syndrome

目的 探讨肠易激综合征 (irritablebowelsyndrome ,IBS)与胃动素 (motilin ,MOT)、胆囊收缩素 (chole cystokinin ,CCK)的关系。方法 采用放射免疫分析法测定 35例正常对照组、2 5例IBS痛泻组、2 0例IBS痛秘组的血浆MOT和CCK值。结果 IBS痛泻组血浆MOT和CCK值明显高于IBS痛秘组和正常对照组 ,差异有显著性 (P <0 .0 5 ) ;而IBS痛秘组血浆MOT值低于正常对照组 ,其CCK值又高于正常对照组 ,但两者差异无显著性 (P >0 .0 5 )。结论 血浆MOT和CCK值与IBS痛泻者有较密切的关系 ,提示MOT和CCK水平增高可能是IBS痛泻组患者腹痛腹泻的因素之一。

Objective To investigate the relationship between the irritable bowel syndrome (IBS) and the plasma motilin (MOT) and cholecystokinin(CCK) levels. Methods The patients with IBS were divided into pain with diarrhoea group and pain with constipation group. Plasma motilin and cholecystokinin levels were detected by radiioimmunoassay in both two IBS groups and in normal group.Results The results showed that MOT and CCK levels of pain with diarrhoea group was higher than that of pain with constipation group and of the normal group respectively, ( P < 0.05 ). Though the plasma MOT and CCK levels of pain with constipation group were lower but higher than that of the normal group, they had no significance ( P >0.05).Conclusion Plasma MOT and CCK have an intimate relations with pain and diarrhoea group of IBS which indicates that the higher concentrations of plasma MOT and CCK might be factors in the pain with diarrhoea group of IBS.