肝硬化患者红细胞免疫功能与脂质过氧化关系的研究

The study on the relationship between red-blood cell immunity and lipid peroxidation in patients with hepatic cirrhosis

探讨肝硬化患者红细胞免疫功能的变化及其与脂质过氧化的关系。应用红细胞酵母菌花环法测定红细胞免疫功能 ,并采用化学比色法测定血浆丙二醛 (MDA)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH -Px)含量。其中肝硬化患者 31例 ,健康对照 30例。肝硬化组RBC -IC花环率明显提高 ,P <0 .0 5 ;而RBC -C3b受体花环率与正常人无显著性差异 (P >0 .0 5 )。肝硬化组SOD、GSH -Px、SOD/MDA低于正常 (P <0 .0 1) ;而MDA明显高于正常 (P <0 .0 1)。线性相关分析显示 ,RBC -C3b花环率与MDA呈显著负相关 (r= 0 .42 3,P <0 .0 5 )。RBC -ICR与MDA明显正相关 (r=0 .5 2 3,P <0 .0 5 )。肝硬化患者红细胞免疫粘附功能降低 。

To study the red blood cell immunity and to assess the relationship between red blood cell immunity and lipid peroxidation(LP).The red blood cell C3b receptor rosette(RBC C3bRR)and red blood cell immune complex rosette(RBC ICR)were measured in 31 patients with cirrhosis and 30 normal controls.The levels of malondialdehyde(MDA),superoxide dismutase(SOD) and Glutathione peroxidase were mearured by chemocolorimetry.RBC ICR was significantly higher in patients with cirrhosis than in controls.And RBC ICR was unchanged.The levels of superoxide dismutase,Glutathione peroxidase and SOD/MDA ratio were significantly lower in patients with cirrhosis than in controls.On the contrary,the contents of malondialdehyde were significantly increased.RBC ICR was positively correlated with MDA.The lowed red blood cell immune adhension function was closely associated with the lipid peroxidation injury.