牙周炎患者龈沟液中细胞因子水平的变化

The Changes in Cytokines Levels in Gingival Crevicular Fluid in Patients with Periodontitis

研究牙周炎患者龈沟液 (GCF)中细胞因子水平的变化及其临床意义。用RIA检测了成人牙周炎组 (AP组 ) 16例 2 6个牙 ,快速进展型牙周炎组 (RPP组 ) 19例 2 9个牙和牙周健康者对照组 (H组 ) 2 4名 31个牙的GCF中白介素 1β(IL - 1β)、肿瘤坏死因子α(TNFα)、白介素 6 (IL - 6 )和转化生长因子α(TGFα)含量的变化并记录受检牙的牙周破坏指数PD、AL。结果表明 :AP组、RPP组患者GCF中IL - 1β、TNFα、IL - 6水平明显高于对照组(P <0 .0 5和P <0 .0 1)且与PD、AL呈显著正相关 (P <0 .0 1) ;TGFα 水平明显低于对照组 (P <0 .0 1) ,与PD、AL呈显著负相关 (P <0 .0 1)。提示IL - 1β、TNFα、IL - 6、TGFα

In order to explore the changes in cytokines levels in gingival crevicular fluid (GCF) and their clinical significance in periodontitis patients, the contents of IL-1β, TNF α,IL-6 and TGF α in GCF from 26 teeth of 16 patients with adult periodontitis (AP), 29 teeth of 19 patients with rapidly progressive periodontitis(RPP) and 31 teeth of 24 normal controls (H group) were determined by RIA, and the clinical periodontoclasia indices of PD?AL were recorded. The results showed that in patients with AP and RPP the IL-1β, TNF α and IL-6 were significantly higher than those in H group, and they were positively correlated to PD and AL; but TGF α was significantly lower than that in H group and it was negatively correlated to PD and AL.The above results indicate that IL-1β, TNF α,IL-6 and TGF α were the most important cytokines which have a hand in alveolar resorption of periodontitis.