丹参注射液对稳定型心绞痛患者抗氧化作用的研究

Effect of salvia miltiorrhiza injection on antioxidation in patients with stable angina

目的 研究丹参液对稳定型心绞痛患者抗氧化作用。方法 将 80例稳定型心绞痛患者随机分成两组 ,分别用基础药物治疗和加用丹参液治疗 10天 ,监测临床指标及氧化指标 :丙二醛 (MDA)、超氧化物歧化酶 (SOD)、谷胱苷肽过氧化物酶 (GSH Px)。结果 ①两组比较 ,丹参液组MDA、SOD、GSH Px、SOD/MDA、ΔMDA、ΔSOD、ΔGSH Px明显改善 ,差异有显著性 (P <0 0 5 )。②丹参液治疗后临床症状及心电图改善与氧化、抗氧化指标显著相关 (P <0 0 5 )。结论 丹参注射液对稳定型心绞痛患者具有治疗作用 。

Objective To study antioxidatant effect of SM injection for patients with stable angina. Methods Eighty patients were randomized to received either basic therapy or supplemented with SM for 10 days. In addition to clinical evaluations, we measured markers of oxidative (MDA)and defense against oxidative stress (SOD,GSH Px).Results ①There was significant difference of MDA, SOD, GSH Px, SOD/MDA between two groups ( P <0 05). ②There was a significant correlation between improvement of clinical syndrome, ECG (electric cardiography) and those oxidant and antioxidant variables ( P <0 05). Conclusion SM injection can treat stable angina. Improvement of clinical syndrome of patients with stable angina partly is dependent on antioxidation at least.