小儿肝移植无肝期丙泊酚的药代动力学特点

Pharmacokinetics character of propofol during anhepatic period of pediatric liver transplantation

目的 :研究小儿肝移植无肝期丙泊酚的药代动力学特征。 方法 :5例同种异体原位肝移植患者 ,分别于麻醉诱导及无肝期开始时静脉注射丙泊酚 2 mg/kg,采用反相高效液相色谱法测定血浆中丙泊酚浓度 ,对比两者之间的药代动力学差异。结果 :丙泊酚的药 -时曲线符合开放性三室模型 ,具有分布广 ,清除率高等特性。 结论 :无肝期与诱导期丙泊酚代谢无明显差异 ,推测该药可能存在明显的肝外代谢。

Objective: To investigate pharmacokinetics of propofol during anhepatic period of orthotopic liver transplantation (OLT) in children. Methods: In 5 children undergoing OLT, 2 mg/kg propofol was injected intravenously at the beginning of induction and anhepatic periods respectively. The plasma concentration of propofol was measured by reverse-phase high performance liquid chromatography(RP-HPLC), and the pharmacokinetics character of propofol between anhepatic and inducing periods were compared. Results: Propofol had wide distribution and high clearance, and its plasma concentration-time curves were fitted to a three-compartment open model. Conclusion: There is no difference of propofol metabolism between anhepatic and inducing periods, suggesting that there must be notable extra-hepatic metabolism when propofol used in children undergoing OLT.