人卵巢癌基因治疗的几种方案

Progress in Gene Therapy of Ovarian Cancer

卵巢癌的基因治疗业已取得了很大的进展。重组回旋病毒、腺病毒或非病毒脂质体有可能作为安全、有效的媒介物质 ;分子化学疗法、突变补偿、免疫增强和耐药性变化等基因治疗方法不断得到了发展和完善。部分治疗方案 (特别是单纯疱疹病毒胸腺嘧啶脱氧核苷激酶方案等 )

Considerable progess has been made in gene therapy of ovarian cancer.Recombinant retrovirus,adenovirus and nonviral liposome have been developed for the candidates of vectors.Various gene therapies of ovarian cancer,e.g,molecular chemotherapy,mutation compensation,immunopotentiation and multi drug resistance,are being kept advances and perfects.Some of the gene therapy protocols,including herpes simplex virus thymidine kinase based,adoptive immunotherapy based,active immunotherapy based and multi drug resistance gene based protocols have been on trail or clinical application.