未成熟卵泡黄素化综合征37例临床观察

Multiple Immature Luteinized Follicle Syndrome

目的 :探讨未成熟卵泡黄素化 (MIL F)的发生及诊断。方法 :对 36 3例不孕患者中的 MIL FS37例 (MIL F组 )及 2 0例正常排卵者 (对照组 )进行宫颈评分、B超监测、放免测定血 FSH、L H、E2 、P及腹腔液中 E2 P值 ,并行腹腔镜和子宫内膜活检。结果 :1不孕妇女中 MIL F周期的发生率为 8.75 %。 2 MIL F组月经中期血 FSH、L H值明显低于对照组(P<0 .0 0 1)。 3腹腔镜检查 :MIL F组卵巢上见黄体未见排卵裂孔者 33例 ,腹腔液与血清中 E2 、P值之比均小于 3。MIL F组盆腔疾患发病率高于对照组 (P<0 .0 5 )。结论 :1MIL F是不明原因不孕的原因之一 ;2 MIL FS的诊断尚缺乏简便准确的方法 ;3 MIL

Objectives:To study the occurence and diagnosis of multiple immature luteinized follicle syndrome(MILFS)in infertile women.Methods: Among 363 infertile women,37 cases with MILF were taken as study group and 20 with normal ovulation as control.Serial B ultrasonography,cervical mucus scoring,serum FSH,LH,E 2,P and peritoneal fluid E 2,P were monitered in both groups.Results:The incidence of MILF was 8.75%,and levels of plasma FSH,LH in study group were significantly lower than those in control( P <0 001,respectively)on the mid cycle.Laparoscopy revealed:①In MILF group,no ovulation stigma on the corpus luteum was found in 33 patients.E 2and P values were higher but less than threefold in peritoneal fluid than in plasma.②The incidences of pelvic diseases were significantly higher than those in control( P <0 005).Conclusion:①MILF might be a cause of unexplained infertility.②No simple and accurate methods of diagnosing MILF have been gained by far.③The occuring of MILF might have relative with pelvic disease which can affect the function of hypothalamic pituitary ovarian axis.