电化学治疗乳癌术后局部复发的临床效果

Clinical effect of electrochemical therapy (ECT) on local recurrent breast cancer

目的 探讨电化学疗法对乳腺癌切除后局部复发的治疗效果。方法 用铂金制成电极针 ,其粗径 0 .7mm ,长度为 16cm。局麻下将电极针插入复发癌创面底层 ,电极针之间的距离为 1.5cm ,电极针分为阴极和阳极 ,将其连接在电化学治疗仪上进行通电治疗。常用电压为 6～ 8V ,电流为 40～ 80mA ,电量按肿瘤直径计算 ,每 1.0cm约给 80库仑。结果 电化学治疗 65例乳腺癌术后局部复发癌的临床效果分为完全缓解 (CR ) 3 1例 (47.7% ) ;部分缓解 (PR) 2 0例 (3 0 .8% ) ,改善 (MR) 8例 (12 .3 % ) ;无效 (PD) 6例 (9.2 % )。将CR、PR评为有效 ,其有效率为 78.5 %。结论 乳癌术后局部复发症依然是难治之症 ,对此应用电化学疗法取得了较好效果。本疗法具有简便易行安全有效。创伤小恢复快的特点 ,容易被患者接受。

Objective To study the effect of electrochemical herapy(ECT) on postoperative local recurrent breast cancer.Methods Special electrodes made of platinum were inserted into tumor mass and conneted to ECT instrument.The proper distance between two electrodes was 1.5cm.Electric voltage was about 6～8.0V and electric current ranged from 40mA to 80mA.Electrc quantity was 80C for 1.0cm diameter.Results As for short term results in one year,CR was 47.7%(31/65),PR 30.8%(20/65),NC 12.3%(8/65)and PD 92%(6/65).The effective rate was 78.5%(CR+PR).Conclusions ECT is safe and easy to manipulate with less trauma,which is considered to be an effective method for local recurrent breast cancer.