A型肉毒毒素治疗上半面部皱纹1000例

Treatment of upper-facial wrinkles with botulinum toxin type A in 1000 cases

目的 为了治疗上半面部因表情肌活动产生的皱纹 ,通过注射肉毒毒素到面部相关的肌肉来有效的控制肌肉的活动 ,从而达到柔和和消除面部皱纹的目的。从 1996年开始临床应用至今已有 10 0 0例病例 ,其中眉间纹2 3 5例 ,鱼尾纹 3 80例 ,额纹 3 5 0例 ,鼻背部皱纹 3 5例。方法 一般用 1.5ml生理盐水稀释 5 5单位BOTOX ,并可根据不同的患者调整剂量和浓度。结果 肌肉麻痹的效果通常持续 3～ 6个月不等 ,除 1例出现短暂性的上睑下垂 ,3例出现局部水肿和青紫外 ,无局部或全身副作用。结论 肉毒毒素是暂时性消除上半面部动力性皱纹的安全、有效、简便的治疗方法。

Objective For treatment of winkling in the upper face caused by actions of facial muscles, we injected botulinum toxin type-A into facial muscles leading to its temporary paralysis and weakness. This can produce a significant improvement of wrinkling in face. One thousand patients were injected with BOTOX since 1996. 235 in the corrugator superciliaris, 380 in the orbicularis oculi, 350 in the frontalis muscle and 35 in the dorsum of nose. Methods Dilution was obtained by adding 1.5ml normal saline to 55 IU of BOTOX. The dose used varied according to individial patient. Results The paralysis obtained in the facial muscles was effective lasting for 3～6 months. Neither local nor general adverse effects were noted, except ptosis in 1 patient, edema and ecchymosis in 3 patients. The improvement obtained in facial wrinkles was satisfactory both to the patient and to us. Conclusion BOTOX is a safe, easy-to-use, effective modality for the temporary elimination of hyperfunctioning upper-facial muscles.