乙型肝炎疫苗与卡介苗、百白破混合菌苗的联合免疫效果观察

observation on the Efficacy of Hepatstis B Vaccine Combined lmmune with BCG and DPT

本文报道150名HBsAg阴性产妇所生新生儿在实施计划免疫的同时,1、2组分别接种10μg、20μg乙肝疫苗,3组不接种乙肝疫苗,以了解乙肝疫苗与卡介苗、百白破联合免疫的免疫应答。结果表明:1.2组抗-HBc达到有效保护的(P/N≥5)为93.18％和89.58％,无显著差异;两组均未检出HBV标志物,但是未注射乙肝疫苗组HBV感染达6.67％。乙肝疫苗与卡介苗、百白破联合免疫应答是好的,抗原间无干扰,从而证明乙肝疫苗不但能有效地控制乙型肝炎,并能纳入扩大免疫规划。

In order to study the immune response of HB vaccine combined with BCGand DTP, 150 newborns of HBsAg negative. mothers were divided into threegroups and observed. Babies in groups 1 and 2 were given injection of 10μg,20μg HB vaccine respectively, group 3 had no HB vaccination. But all thethree group were given BCG and DTP by immune plan.The babies in group 1 and 2 whose anti-HBs reached the level of P/N≥5were 93.18% and 89.58% respectively. There is no statistical difference forthe two groups (P>0. 05). Markers of HBV have not been detected in them,but the rate of the HBV infection in the group without injection of HB vaccinereached as high as 6.67%.The immune response of HB vaccine combined with BCG and DTP wasgood, and there had no influence among these antigens.This result showed that HB vaccine may be an effective control of HB andcan be integrated into expanded programme on immunization (EPI).