具有多种浏览器的数字化人脑图谱

Digitized Atlas of the Human Brain with Multi-Browsers

目的 用计算机技术实现基于MR图像的数字化人脑解剖图谱。方法 首先对获取的MR图像进行边缘提取、去除非脑组织等操作 ,再提取感兴趣区 ,分别用虚拟现实建模语言 (VRML)和移动立方体法 (marchingcubes)获得可视化显示 ,并对图谱加解剖标识。用一种基于点约束的变形算法———薄板样条法 (thin platesplines)使基于MR图像的图谱与Talairach标准图谱对准 ,实现图谱到Talairach标准空间的映射。结果 基于中国人 (男、女各一 )头部MR体数据集 ,实现具有多种浏览功能的数字化人脑图谱。该图谱将各种功能集成于一个人机交互式界面中 ,可以任意选取感兴趣区放大、旋转观察 ,对人脑的各个组成部分的名称及其上下级层次结构深入了解 ,逼真的 3D显示图像对脑内部深层结构产生直观的印象。结论 具有多种浏览功能的数字化人脑图谱是人脑解剖教学、神经外科手术计划和引导及人脑组织分类的重要工具。

Purpose Digitized human brain atlas is an important tool for visualization of medical images and investigation of brain science. Methods This paper describes its fundamentals and construction. Multi browser techniques, including VRML based 3D display and cino view, allow to see 3D renderings of many anatomical structures and cross sectional slices and to interact with them. Results The atlas can be used as a tool for anatomy education of human brain, for pre surgical planning and reference , and as a template for segmentation by matching. With thin plate splines, any particular MR volume data can be anatomically labeled. The method resolved better the problem of registration between intensity image of tomography and anatomy atlas without intensity information such as talairach space. Conclusion Besides brain web, 3D datasets of Chinese human heads, both male and female, are included in the system, which could be a prototype of Chinese human brain atlas.