家兔激素性股骨头坏死的血液流变学改变及意义

Role of Hemorrheology in Dexamethasone-induced Femoral Head Osteonecrosis

目的探讨血液流变学改变在家兔激素性股骨头坏死发病机制中的作用。方法雄性家兔30只 ,随机分为激素组 (短期注射地塞米松 )及对照组 (注射生理盐水 ) ,观察血清总胆固醇 (TC)、甘油三脂 (TG)、血液流变学参数、兔股骨头骨陷窝空虚率的阶段性变化。结果实验15、30d ,激素组的TG、TC、全血粘度、血浆粘度显著高于对照组。实验60d ,激素组血清TC、血浆粘度仍然显著高于对照组。激素组35、70d双侧股骨头骨陷窝空虚率均显著高于对照组。结论地塞米松冲击应用可造成家兔血液流变特性恶化 。

Objective To investigate the role of hemorrheology on dexamethasone induced femoral head osteonecrosis by using a rabbit model.Methods 30 male adult rabbits were divided into control group(injected with saline) and DEX group(injected with dexamethasone).Serum total cholesterol (TC), triglyceride (TG), hemorrheological factors and empty bone lacunae were observed in different stages.Results In the 15th and 30th day of the study, serum TG, TC concentrations, empty bone lacunae, blood viscosity and plasma viscosity all increased in DEX group as compared with those in control group. In the 60th day, serum TC concentration and plasma viscosity still kept high level, others have come back to normal ranges. Conclusions A short term application of Dexamethasone may be the cause in the pathogenesis of femoral head osteonecrosis.