延胡索对小鼠学习能力及抗氧化作用的影响

Effect of Yanhusuo on learning capability and anti-oxidation of mice

研究了延胡索对小鼠学习能力及抗氧化作用的影响 .给小鼠按 8g/ (kg·d)、1 6g/ (kg·d)的剂量灌胃延胡索水煎液 ,连续 1 5d ,观察小鼠开场行为 ,测定其免疫器官指数、学习记忆能力、脑中多巴胺 (DA)和 5 羟色胺 (5 HT)含量、心肌和肝脏中丙二醛 (MDA)和脂褐素 (LPF)含量及肝脏中超氧化物歧化酶 (SOD)活性的变化 .结果表明 ,与对照组比较 ,各实验组小鼠在新环境中自发活动显著增加 ,主要免疫器官指数增加 ,学习能力显著提高 ,脑内多巴胺和 5 羟色胺含量显著提高 ,心肌、肝脏中丙二醛和脂褐素含量显著降低 ,肝脏中SOD活力显著升高 .提示延胡索能增强小鼠学习能力和抗氧化作用 .

The effect of Yanhusuo on learning capability and anti-oxidation of mice was studied.Mice were kept on Yanhusuo 8 g/(kg·d) or 1 6 g/(kg·d) for 15 days.The behavior of the opening field and the learning memory were observed.The indexes of main immune organs,the contents of DA and 5-HT in brain,the contents of MDA and LPF in heart and in liver,the activities of SOD in liver were measured.Compared with the control group, the results showed Yanhusuo can obviously improve spontaneous activity o f mice in new environment,increase the index of immune organs,remarkably improve the learning abilities,decrease the contents of MDA and LPF in heart and in liver, increase the contents of DA and 5-HT in brain. Meanwhile,the activities of SOD in liver were signific antly higher as compared with the control group.It can be concluded that Yanhusuo can improve the learning abilities and increase the anti-oxidation of mice.