醋柳黄酮对原发性高血压患者交感神经兴奋性的影响

Effect of Total Flavones of Hippophae Rhamnoides L. on Sympathetic Activity in Hypertension

目的 探讨醋柳黄酮对原发性高血压患者交感神经兴奋性的影响。方法 采用随机同期对照方法 ,观察醋柳黄酮治疗前后原发性高血压患者静息及运动后的心率、血压与血浆儿茶酚胺 (去甲肾上腺素 NA,肾上腺素 A)水平的变化 ,并用钙通道阻滞剂硝苯地平和缓释异搏定作对照。醋柳黄酮组 35例 ,硝苯地平组 33例 ,缓释异搏定组 2 0例。结果 醋柳黄酮对原发性高血压患者的静息心率、血浆儿茶酚胺无影响 ,并能明显抑制等长运动引起的心率、血压与血浆儿茶酚胺水平的变化 ;硝苯地平使静息血浆儿茶酚胺水平升高 ,等长运动后升高更明显 ;缓释异搏定对静息儿茶酚胺无影响 ,但等长运动后仍明显升高。结论 醋柳黄酮发挥降压作用时不影响高血压患者的交感活性 ,且对等长运动导致的交感兴奋有抑制作用。提示醋柳黄酮在高血压靶器官损害的防治中可能有益。

Objective To investigate the effect of total flavones of hippophae rhamnoides L(TFH) on sympathetic nerve activity of essential hypertensive patients and to determine whether TFH possesses inhibitory effect on sympathetic activity after supine isometric exercise. Methods Heart rate, blood pressure and plasma catecholamines of the patients were measured before and after treatment. 88 patients were randomly divided into TFH group( n =35), calcium antagonist nifedipine( n= 33) and verapamil ER( n= 20) group. Results It was shown after 8 weeks of treatment that TFH did not alter the rest heart rate and plasma catecholamine concentration in the patients( P> 0.05). In contrast, nifedipine produced an increase of noradrenaline and adrenaline level( P< 0.01). Isometric exercise may significantly increase the heart rate, blood pressure and plasma catecholamine concentration in hypertensive patients. In TFH group, exercise did not increase the heart rate, blood pressure and plasma catecholamine concentration after treatment. In nifedipine group,however, the same isometric exercise significantly increased the heart rate, blood pressure and noradrenaline concentration after treatment ( P< 0.01). In verapamil group, the plasma catecholamine concentration did not change after treatment, but it was significantly increased after isometric exercise. Conclusions The results suggest that TFH does not alter the sympathetic activity in treatment of hypertension and the inhibitory effect of TFH on sympathetic activity after supine isometric exercise may provide clinical benefits.