嗜银颗粒和嗜银颗粒性痴呆的神经病理学研究

Neuropathological study on argyrophilic grain and argyrophilic grain dementia

目的 探讨嗜银颗粒 (argyrophilicgrain ,AG)的神经病理学及临床意义。方法 对 110例正常人脑、85例神经系统变性疾病的脑标本及 1例嗜银颗粒性痴呆 (AGD)病例 ,进行了嗜银颗粒的病理组织学研究。结果 ( 1)AG在正常人脑中的出现频率为 6 4 % ,进行性核上性麻痹 4 0 0 %、多系统萎缩症 2 9 1%、帕金森病 17 4 %、海绵状脑病 5 0 %。 ( 2 )AG分布在大脑的边缘系统 ,以海马旁回、海马台、颞叶的前部最多。形态因部位而异。 ( 3 )AG常常出现于神经突起上。由直径约 2 0nm ,表面光滑 ,无侧支的直细管样结构组成。结论 AG在正常人脑中可见 ;AG易出现于变性疾病中 ;AGD在临床上可表现老年性痴呆症状。

Objective To investigate the neuropathological and clinical significance of argyrophilic grain (AG). Methods The occurrence frequency and pathohistology in AG of 110 normal human brain cases, 85 neurodegenerative disorder cases and one argyrophilic grain (AGD) case were studied. Results (1) The occurrence frequency of AG are 4 5% to the normal human brains, 40 0% to PSP, 29 2% to MSA, 17 4% to PD and 5 0% to CJD (2) AG distributes in limbic system, and mostly in parahippocampal gyrus subiculum and anterior part of temporal lobe The conformations are different in their positions (3) AG appears at neuronal processes and is composed of straight thin tube like structures which has no branch,and shows smooth surface and a 20 nm diameter. Conclusion AG can be found in normal human brain and be easily found in neurodegenerative disorder In clinical, AGD′s appearing symptoms are similar to AD,but AGD is different from it pathologically and clinically