血清C-反应蛋白诊断妇科感染的临床应用

Serum C-reactive Protein in the Diagnosis of Infective Disease in Gynecology

在119例无感染、轻微感染及感染3组妇科病人术前测定血清C-反应蛋白(C-reactive protein,CRP),白细胞计数(WBC),中性白细胞百分比(N),血沉(ESR)及当日最高体温(T),作为妇科感染指标。结果在3组中,与无感染组相比,轻微感染组CRP及其它指标均无显著差异(P>0.1);而感染组各指标均显著升高(P<0.0005或P<0.001)。与无感染组相比,轻微感染组CRP除敏感性低于ESR及N外(P<0.01或P<0.05),特异性,敏感性,阳性预示价值,阴性预示价值及准确性与其它指标相比,均无显著差异(P>0.5);而感染组CRP的敏感性,阴性预示价值及准确性均显著高于其它指标(P<0.005或<0.01)。故认为CRP为一项较好的感染实验室指标。

Serum C-reactive protein(CRP), erythrocyte sedimentation rate(ESR),white blood cell count(WBC), percentage of neutrophil(N) and body temperature (T)were determined before operations in three groups, noninfective, slightly infective andseverely infective. We found that CRP and other parameters used for determming infectionhad no significant changes between noninfective group and slightly infective group (P>0. 1).These parameters were significantly changes between noninfective group and severely infetivegroup(P<0.0005 or P<0.001). The specificity, sensitivity, positive predictive value(PPV),negative predictive value (NPV) and accuracy of all paramenters were similar (P>0.5).The sensitivity of CRP lower than ESR and N's (P<0.05 or P<0.01) between noninfectivegroup and slightly infective group. The sensitivity, NPV and accuracy of CRP in severelyinfective group were significantly higher than these of other parameters in noninfectivegroup. We suggest that CRP is a better laboratory parameter for detecting infection thanESR, WBC, N and T.