摘要
采用硫代巴比妥酸比色法测定39例急性肾炎患儿血清涎酸(SA),结果急性期为769.2±225.2mg/L,明显高于对照组(415.2±144.9mg/L);恢复期为472.6±134.5mg/L,同对照组比较无明显差异。此外,血清SA上升显著者多数补体下降,肾功能相对较低、血尿及蛋白尿严重,血沉升高者血清SA也明显上升。因此血清SA可作为病情严重程度及活动性的判断指标。
The serum sialic acid (SA) concentration of 39 children with acute glomerulonephritis was spectrophotometrically measured with thiobarbituric acid. The data showed that the level of serum SA of children in acute period was (769.2±225. 2 mg/L) markedly higher than that of control subjects (415. 2± 144. 9mg/L); but that of children in convalescence period was 472.6 il34.5mg/L which was only slightly about normal. The results also revealed that the majority of patients with obviously high level of serum SA had a reduction in serum complement, comparatively declined renal function, severe hematuria, gross proteinuria and high erythrocyte sedimemtation rate. Our results suggested that serum SA may be one of the markers for evaluation of the severity and the activity in kidney disease.
关键词
肾小球肾炎
神经氨酸类
儿童
neuraminic acids
glomerulonephritis
child
