百里酚的合成研究

STUDY ON SYNTHESIS OF THYMOL

以间甲酚、发烟硫酸和异丙醇为原料 ,硫酸作催化剂 ,经磺化与烷基化两步反应合成了百里酚。对其反应条件进行了优化 ,所得最佳工艺条件为 :磺化反应时间 2 h,磺化反应温度 1 1 0～ 1 2 0℃ ,烷基化反应时间 5h,烷基化反应温度 1 2 0℃ ,间甲酚 /异丙醇 (物质的量比 ) =1 .2 ,间甲酚 /烷基化催化剂硫酸 (物质的量比 ) =4 .0 ,在此条件下百里酚产率为 3 8.4 %

Thymol has been synthesized using mcresol, fuming sulfuric acid and isopropyl alcohol as raw materials and sulfuric acid as catalyst. In order to obtain the optimum conditions for preparing thymol, the Uniform Design has been employed, the results showed that sulfonation time 2 h, sulfonation temperature 110~120 ℃, alkylation time 5 h, alkylation temperature 120 ℃, the mol ratio of raw materials (mcresol/isopropyl)= 1.2 and the mol ratio of mcresol/alkylation catalyst sulfuric acid = 4.0, and the yield of thymol is 38.4%.