雷公藤对男性性激素的影响

EFFECT OF MULTI-GLYCOSIDES OF TRIPTERIGIUM WILFORDII(GTW) ON BLOOD SEX HORMONES IN MEN

患轻度银屑病,无其它系统病,成年已婚具有正常生育男子26例。口服GTW20mg/天连服4-6个月后停药,即精子参数达不育标准3个月后停药。随访观察4～5个月,至精子参数恢复服药前水平后3个月终止观察。服药前1周,服药期间和停药后每月检查精液,测定血中FSH、LH和T浓度。结果表明,服药后2月,精子密度和活率指标达不育水平,停药2月,精子检查指标恢复至服药前水平。在服药期间,血清LH和T浓度有轻度的升高,停药后恢复正常。血清FSH浓度自始至终无显著性变化。

In the present study, 26 fertile men suffering from mild psoriasis requiring GTW treatment were recruited. GTW 20mg/day were given orally for 4-6 months. Semen indices and serum FSH, LH and Testosterone(T)were determined before, and regularly during and after treatment for up to 12 months. Results indicated that two months after treatment, the sperm density and particularly the motility decreased significantly. Two months after withdrawal of GTW, they restored to pretreament levels. The serum LH and T levels were slghtly higher in the treatment period then the baseline value prior to treatment(P>0.05). After cessation of drug administration, they were recovered to the pretreatment value. The serum FSH level was not singificantly change during and after treatment, in comparison with the pretreatment baseline. It was concluded that GTW can cause reversible infertility with no significant change in blood sex hormones in men