儿童1型糖尿病患者血清瘦素与C-肽水平变化的研究

Changes of serum leptin and c-peptide level in children with type 1 diabetic mellitus

为探讨儿童 1型糖尿病发病机理与瘦素的相互关系 ;应用放射免疫分析的方法 ,对 6 5例儿童 1型糖尿病 (其中 31例用胰岛素治疗前后 )和 30例正常对照者血清当中的瘦素和C -肽水平进行检测分析 ;结果表明 ,正常对照组与儿童 1型糖尿病患者血清中瘦素及C -肽水平比较有显著性差异 (P <0 .0 1) ,31例患者治疗前后瘦素和C -肽水平变化有显著性差异 (P <0 .0 1) ,且瘦素和C -肽之间的水平变化呈正相关 ,瘦素 /C -肽的比值与正常对照组及治疗后比较有显著性差异。说明瘦素参于儿童 1型糖尿病发病 ,瘦素水平的变化可能与 1型糖尿病的发生、发展及并发症的发生有着十分密切的关系 ,可为临床诊断治疗及合并症的发生提供新的线索。

To deplore the relationship between leptin and c-peptide in children with type 1 diabetic mellitus (DM). The levels of serum leptin and c-peptide(C-P) in 65 type 1 DM children (including 31 before and after insulin treatment) and 30 normal controls were measured by radioimmunoassay (RIA). The results found that there was significant differences ( P <0.01) in leptin and C-P between DM children and normal controls, also in 31 DM children before and after treatment. It showed a positive correlation between leptin and C-P. The changes of the leptin/C-P ratio in DM children compared with normal controls and that before and after treatment were also significantly different. It suggested that leptin may have close relationship in the development, progress and the occurrence of complications in children with DM and also provide a new clue for their diagnosis treatment and complication occurrence.