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^(99m)Tc-MIBI测定门静脉压力分析肝硬化病情及评价疗效

Measurement of portal vein pressure by ^(99m)Tc-MIBI for the evaluation of the staging and therapeutic effect in cirrhosis
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摘要 采用99mTc -MIBI经直肠给药测定 5 4例肝硬化患者各组肝功能的心 /肝 (H/L)比值及门静脉压力 (PVP) ,结果Child -A、B、C级各组H/L分别为 0 .4 9± 0 .18(2 1)、0 .6 9± 0 .16 (15 )、0 .91± 0 .2 1(18) ;PVP分别为 2 .2 2± 0 .5 7(2 1)kPa、2 .85± 0 .38(15 )kPa及 3.5 4± 0 .6 5 (18)kPa。而对照组的H/L及PVP分别为 0 .30± 0 .12 (16 )kPa及 1.6 1± 0 .384 6kPa。Child -A、B、C级各组分别与对照组及各组之间用t检验比较 ,除Child -B与C级组PVP无显著性差异 (P >0 .0 5 )外 ,其余均有非常显著性差异 (P <0 .0 0 1)及显著性差异 (P <0 .0 5 )。对 16例肝硬化患者治疗前后H/L及PVP进行测定 ,服药前、后H/L分别为 0 .73± 0 .16 (16 )及 0 .4 7± 0 .18(16 ) ;门脉压力分别为3.0 0± 0 .5 5 (16 )kPa及 2 .2 0± 0 .6 2 (16 )kPa ,作配对t检验 ,结果治疗前后H/L及PVP差异非常显著。本法测定门脉压力方便 ,无创伤 ,病人能接受 ,而且可分析病情 ,判断疗效 ,对指导制订治疗方案 。 The heart/liver ratio (H/L) and portal vein pressure (PVP) in 54 patients of cirrhosis with various liver function were determined by the rectal administration of 99m Tc-MIBI, The H/L ratio in Child A (21 cases), Child B (15 cases) and Child C (18 cases) group was 0.49±0.18, 0.69±16 and 0.91±0.21 respectively, whereas the PVP was 2.22±0.57kPa, 2.85±0.38kPa and 3.54±0.65kPa respectively. In normal controls (16 cases), the H/L ratio and PVP was 0.30±0.12 and 1.61±0.38kPa. There was no significant difference in PVP between Child B and C groups, but has very significant ( P <0.001) and significant ( P <0.05) difference of H/L ratio and PVP in remaining groups after t test. In 16 cirrhotic patients the H/L ratio and PVP was 0.73±0.16 and 3.00±0.55 before treatment, and become 0.47±0.18 and 2.20±0.62kPa after treatment, there was also very significant difference after t-test. It was concluded that this method for the determination of PVP is not only convenient, but also atraumatic and acceptable for the patient. Thereby, it has unique value for the staging, monitoring therapeutic effect, guiding treatment protocol and jndging the prognosis etc. in cirrhotic patients.
出处 《核技术》 CAS CSCD 北大核心 2001年第11期911-914,共4页 Nuclear Techniques
关键词 ^99MTC-MIBI 直肠给药 肝硬化 门静脉压力 疗效评价 测定 锝99 诊断 甲氧基异丁基异腈 放射性核素 标记物 m Tc-MIBI,Reagent put into rectum,Cirrhosis, Portal vein pressure, Estimating curative effect
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  • 1国毓智,中华核医学杂志,1990年,10卷,154页
  • 2国毓智,中华核医学杂志,1990年,10卷,54页
  • 3孙宏训,肝脏病学,1990年
  • 4魏文汉,病理生理学,1984年
  • 5团体著者,实用内科学(第7版),1981年

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