新型心血池显像剂^(99)Tc^mN-DCHDTC的制备及其生物分布研究

Preparation and Biodistribution of ^(99) Tc^mN-DCHDTC as a New Blood Pool Imaging Agent

以 Sn Cl2 · 2 H2 O为还原剂、丁二酰二酰肼 (SDH)为 N3 -提供体制备 [99Tcm N]int2 + 中间体 ,然后与配体二环己基二硫代氨基甲酸盐 (DCHDTC)进行配体交换反应制得放化纯度大于 95 %的99Tcm N- DCHDTC。99Tcm N- DCHDTC在制备后放置 6 h放化纯度不变 ,分配系数 lg P=1.19,电泳实验结果表明其为电中性配合物。小鼠体内生物分布结果显示 :99Tcm N- DCHDTC在血中有较高的浓集 ,在注射后 30 min时 ,R(血 /心 )、R(血 /肺 )、R(血 /肝 )分别为 5 .2 7、1.31、1.0 7。 99Tcm N-

Tc mN DCHDTC(DCHDTC: dicyclohexyl dithiocarbamate) is prepared through a two step ligand exchange reaction by using SnCl 2·2H 2O as reduction agent and SDH(succinic dihydrazide) as a donor of nitride nitrogen atom(N 3- ). The radiochemical purity of the product is over 95% by TLC. 99 Tc mN DCHDTC is stable over 6 h at room temperature. The lg P is 1.19.The electrophoresis results show the complex is neutral. The biodistribution results in mice indicate the complex has high blood uptake. The uptake ratios of blood/heart, blood/lung and blood/liver are 5.27,1.31 and 1.07 at 30 min post injection respectively. The results for the complex suggest that it will be potentially useful as a blood pool imaging agent.