新生儿缺氧缺血性脑病的临床及凝血因子的研究

THE CLINICAL STUDY ON HYPOXIC-ISCHEMIC ENCEPHALOPATHY (HIE) AND COAGULATION FACTORS IN NEWBORN

研究新生儿缺氧缺血性脑病 (HIE)的凝血因子活性减低与临床出血的关系上 ,我们运用AcL2 0 0型全自动凝血仪及配套试剂对 2 5例患儿及 2 5例无临床出血的正常新生儿进行凝血因子检测。结果表明患儿各种凝血因子活性减低与正常对照有显著性差异 (P <0 0 1 )。凝血因子减少在 4个以上占 6 8% ,多以Ⅱ、Ⅶ、Ⅸ、Ⅹ及Ⅺ、Ⅻ因子复合缺乏。结论 1 .HIE患儿的凝血因子活性减低 ,个数减少与临床出血有明显的正相关。 2 .发病原因与缺氧缺血使脑组织损伤 ,维生素K缺乏 ,肝脏发展不全或感染有关。应加强对新生儿的防治。

To study the relationship between the reduce of activity about coagulation factors in newborn with hpoxic ischemic encephalopathy (HIE) and the clinical bleeding, using 25 patients with HIE and 25 controls who showed no bleeding were tested by applying apparatus and regent. Results showed obvious lower on the activity of all coagulation factors than all of controls. The activity showed significant difference ( P <0 01) of the patients, the ones whose factors had reduced more than 4 kinds 68%, including Ⅱ?Ⅶ?Ⅸ?Ⅹ?Ⅺ?Ⅻ. Therefore,it is coucluded: 1. The reduce of activity and number of coagulation factors had significantly positive relation to the newborns with HIE and controls; 2.The cause was related to the hypoxic ischemic brain damage, the deficiency of Vit K, the imperfection of liver development and infection. So must be enhance the protection for newborn.