慢性肾功能不全患者血浆同型半胱氨酸水平检测

Determination of plasma homocysteine concentrations in patients with chronic renal failure

目的：研究慢性肾功能不全（ＣＲＦ）患者血浆同型半胱氨酸（ＨＣＹ）浓度与健康人的差异，以及ＣＲＦ患者不同阶段ＨＣＹ浓度与肌酐水平的关系。方法：采用荧光偏振免疫法（ＦＰＩＡ），对９９例ＣＲＦ患者和４５名健康志愿者进行血浆ＨＣＹ浓度测定。结果：不同阶段的 ＣＲＦ患者的ＨＣＹ水平均高于健康人组，且具有高度统计学差异（Ｐ＜０．０１）；ＣＲＦ患者 ＨＣＹ浓度随着肌酐水平的升高而升高。结论：临床应监测ＣＲＦ患者的ＨＣＹ血浆浓度，并对高ＨＣＹ血症患者给予相应的治疗，以减少闭塞性血管病变率．

AIM: To study difference of plasma homocysteine (HCY) concentrations betwecn chronic renal failure patients (CRF) and healthy volunteers. To determine whether creatinine levels affected plas- ma HCY concentrations. METHODS: Ninty-nine CRF patients and 45 healthy volunteers were included in the study. Plasma concentrations of HCY was determined by fluorescence polarization immunoassay (FPIA). RESULTS: ①Compared with the healthy group, the plasma HCY concentrations at different stages were higher, and the differences were statistically significant (P<0.01). ② With the increasing of creatinine levels, the trendency of concentrations of HCY in plasma was going up. CONCLUSION: It is necessary to monitor the plasma concentrations of HCY in patients with CRF, and corresponding treatment should be given to hyperhomocysteine patients.