糖尿病神经病变血清抗神经节苷脂抗体的临床观察

Serum anti-gangliosides antibody in typy 2 diabetes mellitus patients with peripheral neuropathy

目的 探讨 2型糖尿病周围神经病变 ( DPN)与血清抗神经节苷脂抗体 ( anti- GS- ab)之间的关系。方法 受试者分为三组 [糖尿病无神经病变组 ( DM组 ) ,DPN组 ,对照组 ],每组 3 0例。采用固相酶免疫法测定各组 anti- GS- Ig M- ab、anti- GS- Ig G- ab,并行糖化血红蛋白 ( Hb A1C)、神经传导速度测定。结果 DPN患者 anti- GS- Ig M- ab的阳性率为 4 6.67% ,明显高于对照及 DM组 ,并与病程、神经病变的临床分级及 Hb A1C呈显著正相关。结论 anti- GS- ab在 DPN的病理过程中起重要作用 ,对 DPN的诊断及病情判断有参考价值。

Objective To ascertain the relationship between diabetic peripheral neuropathy(DPN) pathogenic factors and serum anti gangliosides antibody(anti GS ab) in type 2 diabetes mellitus (2TDM).Methods The Ninty subjects were divided into three groups, including diabetes with non peripheral neuropathy (DM group), DPN group,healthy control group (N group), every group including 30 people. The anti GS IgM ab 、anti GS IgG ab were detected by solid enzyme immunoassay.The Glycosylatedhemoglobin(HbA1c ) and the speech of nervous conduct were measured. Results The positive rate of anti GS IgM ab in DPN group was 46.47%.It was obviously higher than N group and DM group. also sinificantly positive correlated with DPN clinical classification(DPNC) 、course and HbA1c.Conculusion Anti GS Ab plays an important role in DPN pathological process. It has reference value in diagnosis and condition judgement in DPN.