尼莫地平对脑梗死患者康复期认知功能干预的研究

A study on the efficacy of nimodiping in cognitive rehabilitation of cerebral infarction

目的 :探讨尼莫地平对脑梗死康复期认知干预的有效性。方法 :①用 2 4月龄自然老化大鼠作为实验模型 ,灌胃给予尼莫地平 30d ,与同月龄大鼠和 8月龄青年鼠作对照研究。②将 6 7例脑梗死后认知障碍患者随机分为尼莫地平治疗组和对照组 ,治疗组口服尼莫地平 30mg ,每日 2次 ,服用 6个月。两组均于发病后 3周和 6个月时给予改良长谷川量表测评 ,对评分结果进行自身对照和组间比较 ,并对年龄、日常生活活动能力和社会活动功能等相关因素进行分析。结果 :老年大鼠用尼莫地平治疗 1个月后水迷宫实验时程 (33 4± 13 95s)和错次 (2 6± 0 7次 )均较对照组 (79 3± 30 90s及 5 1± 2 2次 )显著好转 (P <0 0 5 ) ,跳台实验两组无显著差异 (P >0 0 5 ) ;临床观察中 ,Barthel指数、社会功能活动调查表和年龄作为相关因素观察指标 ,在单因素分析中均无显著差异 (P >0 0 5 ) ;尼莫地平治疗组与对照组的疗效比较无统计学差异 (P >0 0 5 )。结论 :尼莫地平对脑梗死后认知功能康复无明显有效干预作用。

Objective:To study the efficacy of nimodipine in cognitive rehabilitation of the cerebral infarction.Method:①Experimental animal models were created in 24 months old Wistar mice,which were treated with nimodipine.The result were compared among the drug treated group,non treated of the same age mice group and 8 months young mice group.②Clinical research of nimodipine was conducted in 67 cerebral infarction patients with cognitive impairments.HDS was used as mesuring tool,and analyse the related factors such as age,Barthel index and FAQ.Result:After one month treatment of nimodipine, significant differences between drug dealing and non drug dealing groups were showed in the Y maze discrimination learning experiment( P <0 05), the time duration and errors were 33 4±13 95s and 2 6±0 7times verse 79 3±30 90s and 5 1±2 2times respectively in the two groups;No significant different result was found in one trial passive avoidance response experiment( P >0 05);Single factor analysis (including Barthel index,FAQ and age)did not show significances( P >0 05);There is no statistical differences between nimodipine treated patients and non drug treatment patients( P >0 05).Conclusion:Nimodipine showed no efficiency to cognitive rehabilitation in cerebral infarctions.