A型肉毒毒素治疗头-颈部运动病变

Botulium A Toxin treatment for cranial-cervical movement disorders

目的 探讨 A型肉毒毒素 ( BTX- A)治疗头 -颈部运动病变的临床疗效和不良反应。方法 对 193例患者 (其中面肌痉挛 12 7例、眼睑痉挛 3 1例、Meige综合征 2 9例、痉挛性斜颈 6例 )采用局部多点注射法于痉挛肌肉注射 BTX- A,并随访观察。结果 面肌痉挛、眼睑痉挛和 Meige综合征的治疗有效率均为 10 0 % ,作用持续时间分别是 ( 15 .8± 5 .0 )周、( 13 .4 7± 8.1)周和 ( 12 .3±2 .3 )周 ;痉挛性斜颈的治疗有效率为 83 .4 % ,作用持续时间为 ( 17.1± 5 .7)周。副作用局限、轻微且可逆。结论 BTX- A局部注射治疗头 -颈部运动病变的首选方法之一。

Objective To evaluate the clinical efficacy and side effects of botulinum toxin type A (BTX A) injections for treatment of cranial cervical movement disorders.Methods One hundred and ninety three patients were treated with multifocal intramuscular injections of small doses of BTX A in spasm muscles and followed up.Results Of 127 cases with hemifacial spasm, 31 blepharospasm and 29 Meige's syndrome, the effective rates were all 100% and the average relief duration was(15.8±5.0)wk,(13.4±8.1)wk and (12.3±2.3)wk, respectively. Of 9 cases with spasmodic torticollis, the effective rate was 83.4%, and the average relief duration was( 17.1±5.7)wk. The side effects were local, mild, transient and reversible. Conclusions The local injection of BTX A is a safe and effective means for the treatment of cranial cervical dystonia.