不同剂量碘化钾缓释片和胶囊的驱铅作用比较

Chelating lead effect of potassium lodide delay release tablets and capsules with differential dose

目的 :比较不同剂量碘化钾缓释片和胶囊的驱铅作用。方法 :分成 4组。A组口服碘化钾胶囊 1g·d- 1,B组口服碘化钾缓释片 1g·d- 1,C组口服碘化钾胶囊 0 .5 g·d- 1,D组口服碘化钾缓释片 ,0 .5 g·d- 1,疗程 4wk。观察尿铅排泄 ,并比较用药前后血铅、血锌卟啉 (ZPP)、δ 氨基脱水酶 (δ ALA)及甲状腺素 (T3,T4 )浓度。结果 :4组均有不同程度增加尿铅排泄 ,降低血铅、尿ZPP和δ ALA作用。T3,T4 治疗前后差异有显著意义。口服碘化钾 1g胶囊制剂不良反应最大 ,主要表现为乏力、上腹隐痛 ,分别为 3 1%和 45 % ;口服缓释片 0 .5 g·d- 1,不良反应最小 ,5 %有乏力和口干口苦。结论 :碘化钾具有驱铅作用 ,推荐成人剂量为 0 .5 g·d- 1,且以缓释片为宜。

AIM: To compare chelating lead effect of potassium iodide delay release tablets and capsules with differential dose. METHODS: Two handred and sixty persons exposed to lead were divided into 4 groups. Group A took KI capsules 1 g·d -1 by oral for 4 wk, group B took KI table 1 g·d -1 by oral for 4 wk, group C took KI capsules 0.5 g·d -1 by oral for 4 wk and group D took KI table 0.5 g·d -1 by oral for 4 wk. Lead of urine, ZPP, δ ALA, T 3,T 4 were observed. RESULTS: Urine lead excret increased in second day after intake of KI. The maximum of urine lead excret was in third day after intake of KI. The urine lead, ZPP, δ ALA and blood lead were near normal in fourth week. The most severe adverse reaction was epigastrium indisposet (45%) and tired (31%) in group A. Least adverse reaction was tired and thirsty (5%) in group D. CONCLUSION: KI may remove lead by oral intake. The dose of KI tables 0.5 g·d -1 is suitable in adult.