呼吸道粘膜固有微生物种群与咽炎发病的关系

Relationship between indigenous microflora of posterior pharyngeal wall and pharyngitis

目的 探讨呼吸道粘膜微生物种群丰度和密度的变化与咽炎的病理学关系。方法 对急性咽炎和慢性咽炎病人及正常人群咽后壁微生物种群进行定位、定性、定量分析。结果 正常人咽粘膜菌群为 4～ 5个菌属 ,6～ 9个菌种 ,以α 溶血性链球菌群、奈瑟菌属、棒状杆菌属、葡萄球菌属、厌氧链球菌群和梭状杆菌属为主 ,分别占可培养微生物的 40 %～ 6 0 %、2 0 %～ 30 %、5 %～ 10 %、4%～8%和 0 %～ 40 %。急性咽炎病原菌检出率流感嗜血杆菌占 6 5 %。结论 外籍菌与原籍菌的演替和消长与急性咽炎的发生、发展有着直接关系 ;固有微生物群落急性感染的微群落构象与慢性感染有显著差别。

Objective To investigate the relationship between the abundance and density of the normal flora in the mucous membrane of posterior pharyngeal wall and pharyngitis. Methods A total of 410 samples of posterior pharyngeal wall were received from patients with acute and chronic pharyngitis and normal persons living in Hohhot Area, Inner Mongolia, from September 2000 to April 2001. Locational, qualitative, and quantitative analyses of the micro flora were made. Results There were 6～9 species of bacteria, belonging to 4～5 genuses, in normal persons′ pharyngeal wall. α hemolytic streptococcus, Neisseria, Corynebacterium, Staphylococcus, Streptococcus anaerobius, and fusiform bacillus accounted for 40%～60%, 20%～30%, 5%～10%, 4%～8%, and 0%～40% respectively of the cultured microornisms. Hemophilus influenzae accounted for 65% of the pathogenic bacteria in acute pharyngitis. There is a close relationship between the succession of the invading organisms and indigenous micro flora and the occurrence and development of acute pharyngitis.Conclusion The internal disorder of the proper microflora in the mucous membrane of posterior pharyngial wall is a characteristic indicator of chronic inflammation of pharynx.